Gastroprotective effect of juanislamin on ethanolinduced. Furthermore, the poor gastric ulcers observed at dose 30mgkg and the very severe gastric ulcers at 50mgkg may be explained by the fact that usually, dosage determines effects. Gastroprotective and antioxidant effects of montelukast on. Peptic ulcer diseases are common and are induced by many factors, including stress, smoking, and ingestion of nonsteroidal antiinflammatory drugs. Protective effect of mirtazapine on indomethacininduced. Quercetin attenuates, indomethacininduced acute gastric.
Gst activity in rat stomach thereby inducing gastric. Shoji kawauchi 1,2, tsutomu nakamura 3, hiroyuki yasui 4, chikako nishikawa 4, ikuya miki 1,5, jun inoue 1,5, sayo horibe 1, tsuneo hamaguchi 2, toshihito tanahashi 1,5, shigeto mizuno 1. Aug 15, 2010 in contrast to proton pump inhibitors, rutin could alleviate indomethacin. After 6 hours of indomethacin administration, rats were. Despite these facts that relate sex hormones and ulcer development, little literature exists regarding the e ect of male sex hormoneon ulcer prevention. Protective effects of naringin in indomethacininduced gastric ulcer. Gastroprotective effect of rutin against indomethacininduced. Nov 26, 2008 the antiulcer activities of 15, 30, and 60 mgkg mirtazapine have been investigated on indomethacininduced ulcers in rats, and the results have been compared with that of the control group. Thirty minutes after administration of the rice extract, rats were orally administered 30 mgkg indomethacin dissolved in 3% nahco 3 to induce gastric lesions.
Nsaids drugs use in pain management have been linked with ulcer and employed in several animal experiments, but the ulcer dose has been conflicting. Based on this objective, three varying doses 30, 40 and 50mgkgbw of indomethacin were respectively given orally to. Gastroprotective effects of glutinous rice extract against. Vitex doniana leaves in indomethacin induced ulcer model in experimental rats. Indomethacin ind is a nonsteroid antiinflammatory agent that is known to induce severe gastric mucosal lesions. Protective roles of spondias mombin and ficus exasperata article pdf available in toxicology reports 51 january 2015 with 399 reads. The present investigation aims to evaluate the possible protective effects of ginger and marshmallow on indomethacininduced gastric ulcer in rats. Severity of gastric ulcers induced by indomethacin in mice is decreased by giving vitamin e which protects gastric mucosa by. Animals were administered inm10 mg5 ml kg by subcutaneous injection. Pdf protective effects of naringin in indomethacin. Black tea and theaflavins assist healing of indomethacininduced. They result from an imbalance between mucosal aggressors and protective mechanisms that include the mucus bicarbonate layer. After the administration of indomethacin to rats, ulcers were observed in the small intestine and expression of cyp3a1, the major isoform of hepatic cyp, was significantly down.
This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacininduced gastric ulcer in rats. In order to further expound the efficacy of lzd as an antiulcerative agent, the current study was undertaken to investigate the gastrointestinal protective effect of lzd against indomethacin ind induced duodenal ulcers in rats using esomeprazole eso as a reference drug. Seven groups a g of five animals were used for this study. To study the persistence of the effect of indomethacin, the animals were killed. Garlic decreased inflammatory mediators and increased antioxidants while displaying antiinflammatory and antioxidant effects in rats pretreated with garlic prior to indomethacin. The animals were killed under deep anesthesia 6 h following the administration of indomethacin. Research article the protective effect of testosterone on. Delayed healing of acetic acidinduced gastric ulcers in. This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacin induced gastric ulcer in rats.
Ficus exasperata against indomethacininduced gastric ulcer in rats. Antiulcerogenic activity of lizhong decoction on duodenal. Gastroprotective and antioxidant esects of opipramol on. The animals were divided into five groups 18 rats each. An ulcer of the gastrointestinal tract is defined as a discontinuity in the muscularis. Antiulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats adewoye e.
Dexmedetomidine was administered intraperitoneally at 10, 25, 50 and 100 gkg dosages in distilled water to groups of rats fasted for 24 h. Effects of progesterone on fshstimulated indomethacin. Stomach or peptic ulcers are the most common gastrointestinal tract ailments that affect half of the worlds population. Curative effect of hydrotalcite on indomethacin induced gastric injury. Indomethacin induced gastric lesions indomethacin 30 mgkg body weight was given orally i. Selim department of biochemistry, faculty of pharmacy, tanta university, tanta, elgharbia, egypt abstract gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. Protective roles of spondias mombin and ficus exasperata. Spraguedawley rats 200250 g were given sel, gse, and both by oral gavage for 28 days, and then gastric ulcers were. The aim of this study is to investigate the protective effects of ozone ther apy on gastric ulcer induced by indomethacin, a nonsteroidal antiinflammatory drug, in an experimental rat model. Antiulcerogenic mechanism of magnesium in indomethacin.
Based on this objective, three varying doses 30, 40 and 50mgkgbw of indomethacin were respectively given orally to three groups b, c and d of 48hrfasting rats weighing 20025g. Rutin with its antioxidant activity significantly ameliorated the oxidative stress biomarkers that were deteriorated by indomethacin treatment. Characterization of potential molecular mechanisms. Decreased mucus in cells of gastric glands was also observed in group c as compared to group d. Indomethacin, opipramol, ranitidine and thiopental sodium were obtained from deva holdingturkey, novartisturkey, fakoturkey and ie ulagayturkey respectively. The rats were divided into six groups, each containing six animals and fasted for 24 h. In this regard, an animal model experiment was carriedout to determine the ulcerdose of indomethacin on female wistar rats. Nevertheless, gastric ulcers were present in all the groups treated with indomethacin. Cat and gst activity in rat stomach thereby inducing gas tric ulceration 37. Hydrotalcite plays an important role in the therapy of gastric ulcer induced by nonsteroidal antiinflammatory drugs nsaids, but little is known about the mechanism.
Research paper intestinal and hepatic expression of. Department of physiology, college of medicine, university of ibadan, ibadan, nigeria. Ulceration was induced by a single oral administration of indomethacin 30 mgkg body weight. Nebivolol prevents indomethacininduced gastric ulcer in rats. Subcutaneous sc injections of indomethacin induce a severe enteropathy in rats that resembles human crohns disease. Nebivolol prevents indomethacininduced gastric ulcer in rats nahla e. Mirtazapine decreased the indomethacininduced ulcers significantly at all doses used. The gastric mucosa is continuously exposed to various agents like food condiments, spices, alcohol, acids and. Antiulcerative effect of dexmedetomidine on indomethacin. The rats were deprived of feed twentyfour hours prior to the commencement of ulcer induction though there was free access to water. In normal rats, indomethacin was administered subcutane ously once at 1 mgkg or repeatedly for 2 or 4 wk once daily at 1 mgkg. In the present study, we found that 1 montelukast, lansoprazole, famotidine, and ranitidine all reduced the development of indomethacininduced gastric damage, with this reduction occurring. Protective effect of coptisine free base on indomethacin.
Ulceration in mice was induced by indomethacin 18 mgkg. In this study, we investigated the protective effect of selenium sel, grape seed extract gse, and both on ind induced gastric mucosal ulcers in rats. Curative effect of selenium against indomethacininduced. Nonsteroidal antiinflammatory drugs nsaids such as. Results of the current investigation revealed that indomethacin administration caused significant ulceration in the glandular area of the rat stomach as seen in histopathological examination. Protective effect of vitamin e on indomethacin induced. Cat and gst activity in rat stomach thereby inducing gastric ulceration 37. Fruit pulp extract on indomethacininduced gastric ulcer in albino. Pdf indomethacininduced gastric ulceration in rats. Minocycline in doses of 10 mg, 30 mg, and 100 mgkg was administered orally 1 h before giving indomethacin. To confirm the curative effect of hydrotalcite against indomethacin induced gastric injury, gastric damage was induced by oral administration with a single dose of 30 mgkg indomethacin, and then different drugs or vehicle was treated by oral gavage for 3 days. Esect of opipramol on indomethacininduced gastric ulcer in rats the antiulcer activities of diserent doses of opipramol were investigated in an indomethacininduced ulcer model in. A total of 90 female albino rats weighing 150200gm were included in the study.
Original article gastroprotective effect of oxygenozone. Curative effect of selenium against indomethacininduced gastric ulcers in rats article pdf available in journal of microbiology and biotechnology 214. Pdf protective effects of naringin in indomethacininduced. Quercetin is considered to be an antioxidant with healing effects on many experimental toxic injuries. Therefore, the present study was undertaken to extend this finding by examining the effects of quercetin on indomethacininduced gastric lesions in rats. Thyroid hormones increase stomach goblet cell numbers and. Twentyfour wistar albino rats were used for the study and were. Effect of estrogen on basal, charbacol stimulated acid. May 25, 2018 gastric ulcers are mucosal discontinuities that may extend into the mucosa, submucosa or even deeper. Pyloric ligation was performed for collection of gastric juice, and gastric ulceration was induced by a single intraperitoneal i.
The effects of aqueous leaf extracts of sm and fe on the ulcer index and % inhibition against ulcer in the experimental animals are shown in fig. We designed two experiments to study the preventive and curative effects of hydrotalcite on nsaidsrelated gastric injury in rats and to investigate the relationship between the protective and curative. Indomethacin induced crohns in rats bolder biopath. While only a rat among the rats given 30mgkg indomethacin showed mild form of ulcer, all the rats given 40mgkg indomethacin presented ulcerated gastric mucosa. Therefore, we have studied the influence of some pharmacological agents, such as steroids and salicylazosulfapyridine. After four hours of administration, the animals were sacrificed and the stomach removed. Possible mechanisms underlying the gastroprotective effect of eugenol against indomethacin. In contrast to proton pump inhibitors, rutin could alleviate indomethacin. However, the effects of thyroid hormones on goblet. Mechanisms underlying gastroprotective effect of paeonol. Indomethacininduced ulcers in intact and ovariectomized rats oral indomethacin 25 mgkg produced a 21.
Materials and methods this study was approved by the ethical. Indomethacin inminduced small intestinal ulcers sius induction of small intestinal ulceration was performed according to the previously reported procedure 23. Research paper intestinal and hepatic expression of cytochrome p450s and mdr1a in rats with indomethacininduced small intestinal ulcers shoji kawauchi1,2, tsutomu nakamura3, hiroyuki yasui 4, chikako nishikawa, ikuya miki1,5, jun inoue1,5, sayo horibe1, tsuneo hamaguchi2, toshihito tanahashi1,5, shigeto mizuno1 1. Intestinal and hepatic expression of cytochrome p450s and mdr1a in rats with indomethacininduced small intestinal ulcers. Effect of hydrotalcite on indometacininduced gastric. Gastroprotective effect of garlic in indomethacin induced. Protective effect of coptisine free base on indomethacin induced gastric ulcers in rats. Similarly, the rats given 50mgkg indomethacin presented several. The present study explored the protective effect of paeonol at two dose levels in indomethacin indinduced gastric ulcer in rats. Black tea and theaflavins assist healing of indomethacininduced gastric ulceration in mice by antioxidative action. The pretreatment were continued for 14 days, at the end of the 14th day, rats from group two to group 6 were kept fasting for 24 hrs and indomethacin were administered orally. Antiulcer and hematological properties of virgin coconut oil. Dpn on gastric acid secretion on basal, charbacol stimulated acid secretion and also its effect on indomethacin induced ulcer in ovariectomized rats. Comparative evaluation of the efficacy of cardiospermum.
Gastroprotective effect of vanillin on indomethacininduced gastric. However, no systematic studies have been undertaken to examine this possibility. Effect of selenium and grape seed extract on indomethacin. Gastroprotective effect of rutin against indomethacin. Test for effects of dexmedetomidine on indomethacininduced ulcers in rats we investigated the antiulcerative effect of dexmedetomidine using an indomethacininduced ulcer model in rats 18. Independent groups of rats were pretreated with indomethacin 10 mgkg, lname 70 mgkg or nem 10 mg kg, and subsequently treated with juanislamin 10 mg kg plus ethanol.
Sep 26, 2016 after the administration of indomethacin to rats, ulcers were observed in the small intestine and expression of cyp3a1, the major isoform of hepatic cyp, was significantly down. Indomethacin 5 mgkg was first given subcutane ously to rats fasted for 24 h, and subsequently histamine dihydrochloride 40 mgkg was given subcutaneously three times, at 2. Mucosal lesions induced in the rat intestinal tract by the. The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats. Intestinal and hepatic expression of cytochrome p450s and. To study the persistence of the effect of indomethacin, the animals were killed 2, 4, 6, 12, or 24 h after a single or final administration. Original article gastroprotective effect of minocycline in. Gastroprotective effect of flavonoid quercetin and. Characteristics of inflammatory bowel diseases have been hypothesized to resemble those of the syndrome of intestinal ulceration induced in the rat by nonsteroidal antiinflammatory compounds. The highest burden of this disease both in morbidity and mortality occurs in developing countries. Delayed healing of acetic acidinduced gastric ulcers in rats.
So quercetin and coq10 are effective in protection against indomethacininduced gastric ulcers in. Briefly, inm was suspended in saline with a drop of tween 80 wako, osaka, japan. The aim of this study is therefore to evaluate the protective effects of curcumin against indomethacininduced gastric ulcer in rats. Materials and methods animal grouping forty adult male albino rats 150250 g body weight were obtained from the animal house, faculty. Histology of gastric tissues after induction of ulcers by indomethacin and the effects of resveratrol and l. Shoji kawauchi 1,2, tsutomu nakamura 3, hiroyuki yasui 4, chikako nishikawa 4, ikuya miki 1,5, jun inoue 1,5, sayo horibe 1, tsuneo hamaguchi 2, toshihito tanahashi 1,5. Effect of hydrotalcite on indometacininduced gastric injury. Group a served as the baseline control, gastric ulcer was induced in all the other groups by administering a single dose of 60 mgkg body weight of indomethacin with or without prior 3day. A significant improvement in the level of inhibition against ulceration was. Fortyeight male wistar rats were arranged into six groups. Reddish mucosa with ulcers in pyloric part of stomach was seen in groups c and d. Severity of gastric ulcers induced by indomethacin in mice is decreased by giving vitamin e. Gastroprotective mechanisms of imipramine on indomethacin. The antiulcer activities of 15, 30, and 60 mgkg mirtazapine have been investigated on indomethacininduced ulcers in rats, and the results have been compared with that of the control group.
1364 1282 1196 512 262 163 1161 181 1035 1062 384 117 230 1273 427 818 499 699 439 229 1433 52 404 528 1302 255 1487 1419 208 859 286 339 381 243 1332 563 571 803 1069